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Research & Evidence Library
Evidence-based guides, plain-language explainers, and field notes on canine cancer and personalized mRNA cancer vaccines for dogs, from the RosieVaccine team. Every claim is cited, and where the evidence is thin, we say so.
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Hemangiosarcoma in Dogs: The Silent Killer, and Why It's So Hard to Treat.
Hemangiosarcoma hides until it ruptures, which is why it is so often caught late. What the disease actually is, why the spleen and heart are common sites, and what surgery and chemotherapy really buy in weeks and months, with the survival numbers laid out plainly.
Read the guide →Why Immunotherapy Changes the Math for Hemangiosarcoma in Dogs.
Chemotherapy runs into a ceiling with hemangiosarcoma. Immunotherapy works on a different principle, and a randomized canine trial produced long-term survivors decades ago. Why teaching the immune system to do the work changes the math.
Read the guide →Cancer Vaccines for Dogs: What's Proven, What's Promising, What Failed.
An honest, colour-coded scoreboard of the cancer vaccines being tried in dogs: EGFR/HER2 peptide, frameshift, and whole-tumor approaches, each graded by the strength of the real published evidence rather than the press release.
Read the guide →Beyond Vaccines: Checkpoints, Precision Therapy, and Combinations.
The rest of the toolkit: checkpoint inhibitors, genomic profiling and targeted drugs, eBAT, and the low-evidence adjuncts owners keep asking about, from propranolol to the gut microbiome, and why the future is combinations rather than any single silver bullet.
Read the guide →Personalized Neoantigen Vaccines: The Missing Chapter.
The one immunotherapy approach the rest of the series never covered: personalized neoantigen mRNA vaccines built from a single tumor's own mutations. What they are, the human proof they can work, and a candid look at why hemangiosarcoma is a genuinely hard test.
Read the guide →Catching Cancer Early: What Blood Tests Can and Can't Do for Hemangiosarcoma in Dogs.
Hemangiosarcoma is usually caught late. New blood-based cancer screening (liquid biopsy) promises earlier detection. Here is what the peer-reviewed data actually shows, in plain language, and the honest catch nobody advertises.
Read the guide →How Long Does a Dog Live After a Splenectomy for Hemangiosarcoma? What the Research Says.
Your dog's spleen was removed and it was hemangiosarcoma. How long does she have? One honest answer from one study of 208 dogs, what a median really means, why stage matters most, and whether chemotherapy helps.
Read the guide →AI-Designed Cancer Vaccines for Dogs: What Is Real, and What Exists Today.
You may have read that someone used AI to design an mRNA cancer vaccine for their dog. Here is what that case actually was, what the computational work really does, what is established versus still early, and an honest answer about what does and does not exist in the US today.
Read the explainer →Personalized vs. Shared-Antigen Cancer Vaccines for Dogs: What's the Difference?
One shared target, the whole tumor, or the mutations found only in your dog's cancer. Three strategies, what ONCEPT and VACCS actually tell us, why specificity is both the safety and the efficacy story, and the trade-offs nobody puts on a brochure.
Read the guide →How a Personalized Cancer Vaccine Works: From Tumor DNA to mRNA.
Strip away the jargon and a personalized neoantigen vaccine is a data pipeline that ends in a drug: tumor DNA, the mutations only the cancer has, the targets this dog's immune system can actually see, and an mRNA that teaches T-cells what to hunt. Plus what the human trials really showed.
Read the guide →Melanoma in Dogs: Treatment & Prognosis.
A melanoma in the mouth behaves nothing like one on the skin. A walkthrough of the types, diagnosis and staging, surgery, radiation, chemotherapy, the ONCEPT vaccine, and where personalized mRNA cancer vaccines fit in. Melanoma is the disease where the human evidence is strongest.
Read the guide →Mast Cell Tumors in Dogs: Grade & Treatment.
Mast cell tumours are the most common skin cancer in dogs. The standard of care is well established, but the field is changing fast. A walkthrough of grading, surgery, chemotherapy, targeted therapy like Palladia, and where personalized mRNA vaccines fit in.
Read the guide →How to Read a Canine Cancer Study: A Plain-Language Guide to the Numbers.
Your vet quoted a survival number, and it is running through your head on a loop. What a median actually means, why two honest studies disagree, how cohort size and study design change the answer, and the "44 percent" trap, in plain language.
Read the guide →How to Preserve Your Dog's Tumor Sample for a Cancer Vaccine.
Almost every owner who reaches out asks the same first question: how do I preserve my dog's tumor so it can still be used? Fresh-frozen is the gold standard, FFPE is workable, a matched blood sample is essential, and the one time-sensitive move is putting a hold on the tissue before the lab discards it.
Read the guide →More posts coming soon.
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